Having low valued tiles across all 4 edges & having a mix of low value and high value tiles near each other out of order means you will likely run out of options sooner rather than later.Periodically you have to move away from the strong positioning to make matches of larger tile values, though you should then try to re-establish the same configuration as soon as possible.Try to have tile values increase as you move left to right or top to bottom. Throughout most of the game you want to have a strong corner that has the highest value tiles in it.The game ends when there is no space for a new tile to appear.Each time you make a move a new tile worth 2 appears on the board on the opposite side.For example, by merging a set of 4 tiles into an 8 tile you score 8 points. When tiles merge you add the value of the new tile to your score.Chain reaction merges can happen on some moves, where a set of 2 tiles next to a 4 tile that is next to an 8 tile can all merge into a 16 tile.
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Merge tiles together until you run out of space.